Metabolic loading of guanosine induces chondrocyte apoptosis via the Fas pathway

Abstract

Although the apoptosis of chondrocytes plays an important role in endochondral ossification, its mechanism has not been elucidated. In this study, we show that guanosine induces chondrocyte apoptosis based on the results of acridine orange/ ethidium bromide staining, caspase-3 activation, and sub-G1 fraction analysis. The potent inhibitory effect of… (More)
DOI: 10.1038/emm.2006.47

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