Metabolic inhibition in the perfused rat heart: evidence for glycolytic requirement for normal sodium homeostasis.

@article{Dizon1998MetabolicII,
  title={Metabolic inhibition in the perfused rat heart: evidence for glycolytic requirement for normal sodium homeostasis.},
  author={Jos{\'e} M. Dizon and Daniel Burkhoff and Joseph S. Tauskela and Jia Whang and Philip Jan Cannon and Joseph Katz},
  journal={The American journal of physiology},
  year={1998},
  volume={274 4 Pt 2},
  pages={
          H1082-9
        }
}
Subcellular compartmentalization of energy stores to support different myocardial processes has been exemplified by the glycolytic control of the ATP-sensitive K+ channel. Recent data suggest that the control of intracellular sodium (Nai) may also rely on glycolytically derived ATP; however, the degree of this dependence is unclear. To examine this question, isolated, perfused rat hearts were exposed to hypoxia, to selectively inhibit oxidative metabolism, or iodoacetate (IAA, 100 mumol/l), to… CONTINUE READING

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