Metabolic inhibition enhances Ca(2+)-activated K+ current in smooth muscle cells of rabbit portal vein.

@article{Miller1993MetabolicIE,
  title={Metabolic inhibition enhances Ca(2+)-activated K+ current in smooth muscle cells of rabbit portal vein.},
  author={Alexander Luke Miller and Ezequiel Morales and Normand Leblanc and William C. Cole},
  journal={The American journal of physiology},
  year={1993},
  volume={265 6 Pt 2},
  pages={H2184-95}
}
The effect of metabolic inhibition on macroscopic and single-channel K+ currents in isolated rabbit portal vein myocytes was investigated by patch-clamp technique. Depression of adenosine triphosphate synthesis was produced by 2-deoxy-D-glucose (10 mM) and either cyanide (2 mM) or dinitrophenol (50 microM). Outward quasi-steady-state current evoked by a ramp protocol and outward time-dependent current during step depolarizations were increased during metabolic inhibition. The reversal potential… CONTINUE READING

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