Metabolic inflexibility in skeletal muscle: a prelude to the cardiometabolic syndrome?

@article{Thyfault2006MetabolicII,
  title={Metabolic inflexibility in skeletal muscle: a prelude to the cardiometabolic syndrome?},
  author={John P Thyfault and Randy Scott Rector and Robert C. Noland},
  journal={Journal of the cardiometabolic syndrome},
  year={2006},
  volume={1 3},
  pages={184-9}
}
Peripheral insulin resistance, which is largely dependent on skeletal muscle, is closely linked to the development of the cardiometabolic syndrome. Metabolic flexibility is the capacity for skeletal muscle to acutely shift its reliance between lipids or glucose during fasting or postprandial conditions. Obese and insulin-resistant individuals display elevated intramuscular lipids, impaired vasculature function, decreased fatty add oxidation during fasting, and reduced postprandial glucose… CONTINUE READING

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