Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice.

@article{Wang2014MetabolicIE,
  title={Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice.},
  author={Ling Wang and Ying-Qi Zhai and Li-Li Xu and Chen Qiao and Xiu-Lan Sun and Jianhua Ding and Ming Lu and Gang Hu},
  journal={Experimental neurology},
  year={2014},
  volume={251},
  pages={22-9}
}
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is characterized by the loss of dopaminergic neurons in the substantia nigra. Increasing epidemiological evidence has indicated that type 2 diabetes (T2D) may be implicated in the pathogenesis of PD. However, the exact association and the underlying mechanism remain unclear. In the present study, ob/ob and db/db mice, the well accepted T2D models, were acutely treated with MPTP (1-methyl-4-phenyl-1, 2, 3, 6… CONTINUE READING

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