Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides.

@article{Goon2003MetabolicIO,
  title={Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides.},
  author={Scarlett Goon and Birgit Schilling and Michael V. Tullius and Bradford W. Gibson and Carolyn R Bertozzi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 6},
  pages={3089-94}
}
The lipooligosaccharides (LOS) of Haemophilus ducreyi are highly sialylated, a modification that has been implicated in resistance to host defense and in virulence. In previous work, we demonstrated that H. ducreyi scavenges sialic acid from the extracellular milieu and incorporates those residues into LOS. Here we report that H. ducreyi can use unnatural sialic acids bearing elongated N-acyl groups from three to seven carbon atoms in length, resulting in outer membrane presentation of… CONTINUE READING

References

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  • O. T. Keppler, R. Horstkorte, M. Pawlita, C. Schmidt, W. Reutter
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