Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats.

@article{Kim1996MetabolicIP,
  title={Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats.},
  author={Jason Kim and Jae K Wi and Jang Hyun Youn},
  journal={Diabetes},
  year={1996},
  volume={45 5},
  pages={651-8}
}
To examine whether impairment of intracellular glucose metabolism precedes insulin resistance, we determined the time courses of changes in insulin-stimulated glucose uptake, glycolysis, and glycogen synthesis during high-fat feeding in rats. Animals were fed with a high-fat (66.5%) diet ad libitum for 0, 2, 4, 7, or 14 days (n = 10-11 in each group) after 5 days of a low-fat (12.5%) diet. Submaximal and maximal insulin-stimulated glucose fluxes were estimated in whole body and individual… CONTINUE READING
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