Metabolic imaging of rat brain during pharmacologically-induced tinnitus

  title={Metabolic imaging of rat brain during pharmacologically-induced tinnitus},
  author={A. K. Paul and E. Lobarinas and R. Simmons and David S. Wack and John C. Luisi and J. Spernyak and R. Mazurchuk and H. Abdel-Nabi and R. Salvi},
Although much is known about the perceptual characteristics of tinnitus, its neural origins remain poorly understood. We investigated the pattern of neural activation in central auditory structures using positron emission tomography (PET) imaging in a rat model of salicylate-induced tinnitus. Awake rats were injected with the metabolic tracer, fluorine-18 fluorodeoxyglucose (FDG), once in a quiet state (baseline) and once during salicylate-induced tinnitus. Tinnitus was verified using a… CONTINUE READING


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Performance evaluation of the microPET focus: a third-generation microPET scanner dedicated to animal imaging.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine • 2005
View 2 Excerpts
Highly Influenced

Salicylate induces tinnitus through activation of cochlear NMDA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003
View 3 Excerpts
Highly Influenced

Tinnitus in hamsters following exposure to intense sound

Hearing Research • 2002
View 2 Excerpts
Highly Influenced

Salicylate- and quinine-induced tinnitus and effects of memantine.

Acta oto-laryngologica. Supplementum • 2006
View 2 Excerpts

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