Metabolic handling of orally administered glucose in cirrhosis.

  title={Metabolic handling of orally administered glucose in cirrhosis.},
  author={Yolanta T. Kruszynska and A Meyer-Alber and Froogh Darakhshan and Philip D Home and N Mcintyre},
  journal={The Journal of clinical investigation},
  volume={91 3},
We used a dual-isotope method (oral [1-14C]glucose and intravenous [6-3H]glucose) to examine whether the oral glucose intolerance of cirrhosis is due to (a) a greater input of glucose into the systemic circulation (owing to a lower first-pass hepatic uptake of ingested glucose, or to impaired inhibition of hepatic glucose output), (b) a lower rate of glucose removal, or (c) a combination of these mechanisms. Indirect calorimetry was used to measure oxidative and nonoxidative metabolism. Basal… CONTINUE READING