Metabolic flux analysis of Escherichia coli deficient in the acetate production pathway and expressing the Bacillus subtilis acetolactate synthase.

@article{Yang1999MetabolicFA,
  title={Metabolic flux analysis of Escherichia coli deficient in the acetate production pathway and expressing the Bacillus subtilis acetolactate synthase.},
  author={Yi Yang and Aristos A. Aristidou and K Y San and George N. Bennett},
  journal={Metabolic engineering},
  year={1999},
  volume={1 1},
  pages={
          26-34
        }
}
Several approaches to reduce acetate accumulation in Escherichia coli cultures have recently been reported. This reduction subsequently led to a significant enhancement in recombinant protein production. In those studies, metabolically engineered E. coli strains with reduced acetate synthesis rates were constructed through the modification of glucose uptake rate, the elimination of critical enzymes that are involved in the acetate formation pathways, and the redirection of carbon flux toward… CONTINUE READING
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