Metabolic flux analysis for calcium dependent antibiotic (CDA) production in Streptomyces coelicolor.

  title={Metabolic flux analysis for calcium dependent antibiotic (CDA) production in Streptomyces coelicolor.},
  author={Hong Bum Kim and Colin P. Smith and Jason Micklefield and Ferda Mavituna},
  journal={Metabolic engineering},
  volume={6 4},
The calcium dependent antibiotic (CDA) is a nonribosomal lipopeptide produced by Streptomyces coelicolor. We constructed a metabolic network of more than 400 reactions for the primary and secondary metabolism of S. coelicolor and used computational metabolic flux balancing to investigate some of the factors affecting growth and production of CDA. Computational results indicated that the CDA production was concomitant with growth. Computational specific growth rates were twice as high as the… CONTINUE READING

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