Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy.

@article{Ellis2006MetabolicFI,
  title={Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy.},
  author={D. I. Ellis and R. Goodacre},
  journal={The Analyst},
  year={2006},
  volume={131 8},
  pages={
          875-85
        }
}
The ability to diagnose the early onset of disease, rapidly, non-invasively and unequivocally has multiple benefits. These include the early intervention of therapeutic strategies leading to a reduction in morbidity and mortality, and the releasing of economic resources within overburdened health care systems. Some of the routine clinical tests currently in use are known to be unsuitable or unreliable. In addition, these often rely on single disease markers which are inappropriate when multiple… Expand
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References

SHOWING 1-10 OF 306 REFERENCES
Rapid identification of urinary tract infection bacteria using hyperspectral whole-organism fingerprinting and artificial neural networks.
TLDR
These results demonstrate that modern analytical spectroscopies of high intrinsic dimensionality can provide rapid accurate microbial characterization techniques, but only when combined with appropriate chemometrics. Expand
The rapid differentiation and identification of pathogenic bacteria using Fourier transform infrared spectroscopic and multivariate statistical analysis
Abstract A novel, spectroscopic approach to the differentiation and identification of pathogenic bacteria was elaborated. The method essentially takes advantage of the Fourier transform infraredExpand
Identification of scrapie infection from blood serum by Fourier transform infrared spectroscopy.
We describe a new Fourier transform infrared (FT-IR) spectroscopy-based diagnostic approach, which may provide for the first time a rapid, reliable, and inexpensive blood test for scrapie and relatedExpand
Infrared Spectroscopic Identification of β-Thalassemia
TLDR
IR spectra revealed changes in the secondary structure of hemoglobin from β-thalassemia patients compared with that from controls, in particular, a decreased α-helix content, an increased content of parallel and antiparallel β-sheets, andChanges in the tyrosine ring absorption band. Expand
Raman spectroscopy for identification of epithelial cancers.
TLDR
The discussions outline the likely work required for successful implementation of in vivo Raman detection of early malignancies and the potential for Raman spectroscopy to achieve this goal is evaluated. Expand
Explanatory Analysis of the Metabolome Using Genetic Programming of Simple, Interpretable Rules
TLDR
The combination of FTIR and GP is a powerful and novel analytical tool that improves the understanding of the biochemistry of salt tolerance in tomato plants. Expand
Monitoring the mode of action of antibiotics using Raman spectroscopy: investigating subinhibitory effects of amikacin on Pseudomonas aeruginosa.
TLDR
UV resonance Raman (UVRR) spectroscopy, when coupled with chemometrics and 2D correlation spectroscope, constitutes a powerful approach for the development and screening of new antibiotics. Expand
Detection of pathological molecular alterations in scrapie-infected hamster brain by Fourier transform infrared (FT-IR) spectroscopy.
TLDR
A new approach for the identification of pathological changes in scrapie-infected Syrian hamster brains using Fourier transform infrared microspectroscopy is discussed and provides a useful tool for the exploration of the disease process and the development of rapid diagnostic and screening techniques of transmissible spongiform encephalopathies. Expand
Raman spectroscopy, a potential tool for the objective identification and classification of neoplasia in Barrett's oesophagus
TLDR
Raman spectroscopy appears to provide a highly sensitive and specific technique for the identification and classification of neoplasia in Barrett's oesophagus. Expand
Identification of medically relevant microorganisms by vibrational spectroscopy.
TLDR
It can be concluded that vibrational spectroscopies show high potential as novel methods in medical microbiology. Expand
...
1
2
3
4
5
...