Metabolic features of clear-cell renal cell carcinoma: mechanisms and clinical implications.

@article{Pinthus2011MetabolicFO,
  title={Metabolic features of clear-cell renal cell carcinoma: mechanisms and clinical implications.},
  author={Jehonathan H. Pinthus and Kaitlyn F. Whelan and Daniel Gallino and Jianping Lu and Nathan Rothschild},
  journal={Canadian Urological Association journal = Journal de l'Association des urologues du Canada},
  year={2011},
  volume={5 4},
  pages={274-82}
}
Central to the malignant behaviour that endows cancer cells with growth advantage is their unique metabolism. Cancer cells can process nutrient molecules differently from normal cells and use it to overcome stress imposed on them by various therapies. This metabolic conversion is controlled by specific genetic mutations that are associated with activation of oncogenes and loss of tumour suppressor proteins. Understanding these processes is important as it can lead to the discovery of biomarkers… CONTINUE READING