Metabolic fate of phenprocoumon in humans.

  title={Metabolic fate of phenprocoumon in humans.},
  author={Stephen P Toon and L D Heimark and William F Trager and Robert A O'Reilly},
  journal={Journal of pharmaceutical sciences},
  volume={74 10},
Samples of urine and feces were collected daily from a normal human volunteer who had received a dose of pseudoracemic phenprocoumon [an equimolar mixture of (R)-[12C]- and (S)-[2-13C]phenprocoumon] containing a tracer dose of 10 microCi of [14C]phenprocoumon and analyzed by TLC, HPLC, and GC-MS. After 25 days, 96% of the radiolabeled material was recovered (62.8% in urine and 33.3% in feces). By isotopic dilution and comparison to the Rf values, retention times, and mass fragmentograms of… CONTINUE READING

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