Corpus ID: 32777175

Metabolic fate of menthofuran in rats. Novel oxidative pathways.

  title={Metabolic fate of menthofuran in rats. Novel oxidative pathways.},
  author={K. M. Madyastha and C. P. Raj},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={20 2},
  • K. M. Madyastha, C. P. Raj
  • Published 1992
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
  • Metabolic fate of menthofuran (II) in rats was investigated. Menthofuran (II) was administered orally (200 mg/kg of the body weight/day) to rats for 3 days. The following metabolites were isolated from the urine of these animals: p-cresol (VI), 5-methyl-2-cyclohexen-1-one (VII), 3-methylcyclohexanone (VIII), 3-methylcyclohexanol (IX), 4-hydroxy-4-methyl-2-cyclohexen-1-one (V), geranic acid (XI), neronic acid (XII), benzoic acid (XIII), and 2-[2'-keto-4'-methylcyclohexyl]propionic acid (X… CONTINUE READING
    27 Citations
    Studies on the metabolism of a monoterpene ketone, R-(+)-pulegone--a hepatotoxin in rat: isolation and characterization of new metabolites.
    • 35
    Metabolic disposition of a monoterpene ketone, piperitenone, in rats: evidence for the formation of a known toxin, p-cresol.
    • 17
    • PDF
    Metabolism of (R)-(+)-menthofuran in Fischer-344 rats: identification of sulfonic acid metabolites.
    • 21
    • Highly Influenced
    • PDF
    Effect of ring size in R-(+)-pulegone-mediated hepatotoxicity: studies on the metabolism of R-(+)-4-methyl-2-(1-methylethylidene)-cyclopentanone and DL-camphorone in rats.
    • 4
    • PDF
    Metabolism and toxicity of menthofuran in rat liver slices and in rats.
    • 22
    Metabolic fate of S-(-)-pulegone in rat.
    • 18
    Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats.
    • 6
    • Highly Influenced
    • PDF
    Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity.
    • 6
    Metabolism of (R)-(+)-pulegone in F344 rats.
    • 38
    • PDF