Metabolic fate and hepatocyte toxicity of reverse amide analogs of conjugated ursodeoxycholate in the rat.

@article{Coleman1998MetabolicFA,
  title={Metabolic fate and hepatocyte toxicity of reverse amide analogs of conjugated ursodeoxycholate in the rat.},
  author={James PH Coleman and Lyndon C. Kirby and Kenneth D. R. Setchell and Phillip B. Hylemon and M Pandak and Douglas M. Heuman and Z Rano Vlahcevic},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1998},
  volume={64 1-2},
  pages={91-101}
}
Reverse amide analogs of conjugated bile acids were tested for their effects on the viability of cultured primary rat hepatocytes, for their transport and metabolism in the intact rat, and for their susceptibility to hydrolysis by intestinal bacteria. Succinylnorursodeoxycholanylamide (SNUDCN) and its parent C23 amine showed the same general lack of toxicity toward hepatocytes as the normal conjugates of ursodeoxycholic acid, at concentrations up to 500 microM. The 3alpha,7alpha,12alpha… CONTINUE READING