Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures.


Tanshinone is a group of active diterpenes widely used in treatment of cardiovascular diseases. Here, we report the introduction of genes encoding 3-hydroxy-3-methylglutaryl CoA reductase (HMGR), 1-deoxy-D-xylulose-5-phosphate synthase (DXS) and geranylgeranyl diphosphate synthase (GGPPS) involved in tanshinone biosynthesis into Salvia miltiorrhiza hairy… (More)
DOI: 10.1016/j.ymben.2011.02.003