Metabolic engineering strategies for enhanced shikimate biosynthesis: current scenario and future developments

@article{Bilal2018MetabolicES,
  title={Metabolic engineering strategies for enhanced shikimate biosynthesis: current scenario and future developments},
  author={M. Bilal and Songwei Wang and H. Iqbal and Yuping Zhao and Hong-bo Hu and W. Wang and Xuehong Zhang},
  journal={Applied Microbiology and Biotechnology},
  year={2018},
  volume={102},
  pages={7759-7773}
}
Shikimic acid is an important intermediate for the manufacture of the antiviral drug oseltamivir (Tamiflu®) and many other pharmaceutical compounds. Much of its existing supply is obtained from the seeds of Chinese star anise (Illicium verum). Nevertheless, plants cannot supply a stable source of affordable shikimate along with laborious and cost-expensive extraction and purification process. Microbial biosynthesis of shikimate through metabolic engineering and synthetic biology approaches… Expand
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