Metabolic engineering of muconic acid production in Saccharomyces cerevisiae.

@article{Curran2013MetabolicEO,
  title={Metabolic engineering of muconic acid production in Saccharomyces cerevisiae.},
  author={Kathleen A. Curran and John M Leavitt and Ashty S. Karim and Hal S. Alper},
  journal={Metabolic engineering},
  year={2013},
  volume={15},
  pages={55-66}
}
The dicarboxylic acid muconic acid has garnered significant interest due to its potential use as a platform chemical for the production of several valuable consumer bio-plastics including nylon-6,6 and polyurethane (via an adipic acid intermediate) and polyethylene terephthalate (PET) (via a terephthalic acid intermediate). Many process advantages (including lower pH levels) support the production of this molecule in yeast. Here, we present the first heterologous production of muconic acid in… CONTINUE READING