Metabolic engineering of monoterpene synthesis in yeast.

  title={Metabolic engineering of monoterpene synthesis in yeast.},
  author={Marc J. C. Fischer and Sophie Meyer and Patricia Claudel and Marc Bergdoll and Francis Karst},
  journal={Biotechnology and bioengineering},
  volume={108 8},
Terpenoids are one of the largest and most diverse families of natural compounds. They are heavily used in industry, and the trend is toward engineering modified microorganisms that produce high levels of specific terpenoids. Most studies have focused on creating specific heterologous pathways for sesquiterpenes in Escherichia coli or yeast. We subjected the Saccharomyces cerevisiae ERG20 gene (encoding farnesyl diphosphate synthase) to a set of amino acid mutations in the catalytic site at… CONTINUE READING


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