Metabolic engineering of micronutrients in crop plants

@article{Blancquaert2017MetabolicEO,
  title={Metabolic engineering of micronutrients in crop plants},
  author={Dieter Blancquaert and Hans De Steur and Xavier Gellynck and Dominique Der Straeten},
  journal={Annals of the New York Academy of Sciences},
  year={2017},
  volume={1390}
}
Micronutrient deficiency is a widespread phenomenon, most prevalent in developing countries. Being causally linked to the occurrence of a range of diseases, it affects billions of people worldwide. Enhancing the content of micronutrients in crop products through biotechnology is a promising technique to fight micronutrient malnutrition worldwide. Micronutrient fortification of food products has been implemented in a number of Western countries, but remains inaccessible for poor rural… 
Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification
TLDR
This review focuses on the relevant B-vitamins (B1, B6, and B9) and the role of these vitamins in plant physiology is elaborated, as well their biosynthesis.
From in planta Function to Vitamin-Rich Food Crops: The ACE of Biofortification
TLDR
This review focuses on knowledge about provitamin A (beta-carotene), vitamin C (ascorbate) and the vitamin E group and provides an overview of the functions of these vitamins in planta, followed by highlighting some of the achievements in the nutritional enhancement of food crops via conventional breeding and genetic modification.
Perspectives of folate biofortification of cereal grains
TLDR
Biofortification of cereal grains using translational genomics approaches for enhancement of folate through genome editing in cereals is inevitable to mitigate the folate deficiency in poor remote population in a cost effective manner.
Improving Zinc and Iron Biofortification in Wheat through Genomics Approaches
Globally, about 20% of calories (energy) come from wheat. In some countries, it is more than 70%. More than 2 billion people are at risk for zinc deficiency and even more, people are at risk of iron
Potato biofortification: an effective way to fight global hidden hunger.
TLDR
This review discuss the current scenario of micronutrient malnutrition and various strategies that could be used to overcome it, and shed a light on the genetic variations present in potato germplasm and suggest effective ways to incorporate them into modern high yielding potato varieties.
Global Concerns with B Vitamin Statuses: Biofortification, Fortification, Hidden Hunger, Interactions, and Toxicity.
TLDR
Food fortification efforts have nearly eradicated diseases of extreme B vitamin deficiency, however, subclinical deficiency is still common especially in low-income countries, and more research is needed to provide sustainable and scalable solutions in many parts of the world.
Biofortification: A Promising Approach Toward Eradication of Hidden Hunger
TLDR
This chapter summarizes the different crops fortified with essential nutrients, methods of biofortification, efficacy and economics of the process, monitoring, control measures, aspects of society perspective, and future research to accelerate impact and progress based on interdisciplinary research.
...
...

References

SHOWING 1-10 OF 122 REFERENCES
Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification
TLDR
This review focuses on the relevant B-vitamins (B1, B6, and B9) and the role of these vitamins in plant physiology is elaborated, as well their biosynthesis.
Present and future of folate biofortification of crop plants.
TLDR
Improving nutritional health is one of the major socio-economic challenges of the 21st century, especially with the continuously growing and ageing world population, and major progress has been made over the last decade.
From in planta Function to Vitamin-Rich Food Crops: The ACE of Biofortification
TLDR
This review focuses on knowledge about provitamin A (beta-carotene), vitamin C (ascorbate) and the vitamin E group and provides an overview of the functions of these vitamins in planta, followed by highlighting some of the achievements in the nutritional enhancement of food crops via conventional breeding and genetic modification.
Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways
TLDR
E elite inbred South African transgenic corn plants are created in which the levels of 3 vitamins were increased specifically in the endosperm through the simultaneous modification of 3 separate metabolic pathways, opening the way for the development of nutritionally complete cereals to benefit the world's poorest people.
Folates in Plants: Research Advances and Progress in Crop Biofortification
TLDR
The implication of folates in various aspects of plant physiology and development will be discussed, as the ever-growing need for the enhancement of nutritional quality of crops faces climate change catastrophes or environmental stresses.
Folates and Folic Acid: From Fundamental Research Toward Sustainable Health
TLDR
The state-of-the-art of folate biosynthesis, catabolism, and salvage is provided and the agroeconomical aspect of biofortified crop plants is discussed.
Vitamin Deficiencies in Humans: Can Plant Science Help?[W]
TLDR
While considerable advances have been made in understanding vitamin metabolic pathways in plants, more cross-disciplinary approaches must be adopted to provide adequate levels of all vitamins in the major staple crops to eradicate vitamin deficiencies from the global population.
Plant Ferritin—A Source of Iron to Prevent Its Deficiency
TLDR
Plants overexpressing ferritin may find applications in the development of bioactive food and a crucial achievement would be to develop technologies warranting stability of ferritIn in food and the digestive tract.
Enhancement of folates in plants through metabolic engineering.
TLDR
It is proposed that the expression of an unregulated bacterial GTP cyclohydrolase-1 in plants would increase pterin biosynthesis with a concomitant enhancement of folate levels, and other potential factors regulating folate synthesis are identified, suggesting ways to further enhance folates levels in food crops.
...
...