Metabolic engineering of lignan biosynthesis in Forsythia cell culture.

Abstract

Lignans are a large class of secondary metabolites in plants, with numerous biological effects in mammals, including antitumor and antioxidant activities. Sesamin, the most abundant furofuran-class lignan in sesame seeds (Sesamum plants), is produced by the cytochrome P450 enzyme CYP81Q1 from the precursor lignan, pinoresinol. In contrast, Forsythia plants… (More)
DOI: 10.1093/pcp/pcp156

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