Metabolic engineering of cobalamin (vitamin B12) production in Bacillus megaterium

@article{Biedendieck2010MetabolicEO,
  title={Metabolic engineering of cobalamin (vitamin B12) production in Bacillus megaterium},
  author={Rebekka Biedendieck and Marco Malten and Heiko Barg and B. Bunk and J. Martens and E. Deery and H. Leech and M. Warren and D. Jahn},
  journal={Microbial biotechnology},
  year={2010},
  volume={3},
  pages={24 - 37}
}
Cobalamin (vitamin B12) production in Bacillus megaterium has served as a model system for the systematic evaluation of single and multiple directed molecular and genetic optimization strategies. Plasmid and genome‐based overexpression of genes involved in vitamin B12 biosynthesis, including cbiX, sirA, modified hemA, the operons hemAXCDBL and cbiXJCDETLFGAcysGAcbiYbtuR, and the regulatory gene fnr, significantly increased cobalamin production. To reduce flux along the heme branch of the… Expand
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