Metabolic engineering of astaxanthin production in tobacco flowers

  title={Metabolic engineering of astaxanthin production in tobacco flowers},
  author={Varda Mann and Mark Harker and Iris Pecker and Joseph Hirschberg},
  journal={Nature Biotechnology},
Using metabolic engineering, we have modified the carotenoid biosynthesis pathway in tobacco (Nicotiana tabacum) to produce astaxanthin, a red pigment of considerable economic value. To alter the carotenoid pathway in chromoplasts of higher plants, the cDNA of the gene CrtO from the alga Haematococcus pluvialis, encoding β-carotene ketolase, was transferred to tobacco under the regulation of the tomato Pds (phytoene desaturase) promoter. The transit peptide of PDS from tomato was used to target… CONTINUE READING
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