Metabolic engineering of a reduced-genome strain of Escherichia coli for L-threonine production

Abstract

BACKGROUND Deletion of large blocks of nonessential genes that are not needed for metabolic pathways of interest can reduce the production of unwanted by-products, increase genome stability, and streamline metabolism without physiological compromise. Researchers have recently constructed a reduced-genome Escherichia coli strain MDS42 that lacks 14.3% of its… (More)
DOI: 10.1186/1475-2859-8-2

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