Metabolic engineering of a 1,2-propanediol pathway in Escherichia coli.

  title={Metabolic engineering of a 1,2-propanediol pathway in Escherichia coli.},
  author={Nedim Emil Altaras and Douglas C. Cameron},
  journal={Applied and environmental microbiology},
  volume={65 3},
1,2-Propanediol (1,2-PD) is a major commodity chemical that is currently derived from propylene, a nonrenewable resource. A goal of our research is to develop fermentation routes to 1,2-PD from renewable resources. Here we report the production of enantiomerically pure R-1,2-PD from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes (E. coli gldA or Klebsiella pneumoniae dhaD). We also show that E. coli overexpressing the E. coli methylglyoxal synthase gene (mgs… CONTINUE READING

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