Metabolic engineering of Synechococcus sp. PCC 7002 to produce poly-3-hydroxybutyrate and poly-3-hydroxybutyrate-co-4-hydroxybutyrate.
@article{Zhang2015MetabolicEO, title={Metabolic engineering of Synechococcus sp. PCC 7002 to produce poly-3-hydroxybutyrate and poly-3-hydroxybutyrate-co-4-hydroxybutyrate.}, author={Shuyi Zhang and Yang Liu and Donald A. Bryant}, journal={Metabolic engineering}, year={2015}, volume={32}, pages={ 174-183 } }
34 Citations
Prospect of Synechocystis sp. PCC 6803 for synthesis of poly(3-hydroxybutyrate-co-4-hydroxybutyrate)
- Materials Science
- 2020
Engineering of Halomonas bluephagenesis for low cost production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from glucose.
- Biology, EngineeringMetabolic engineering
- 2018
Engineering Halomonas bluephagenesis TD01 for non-sterile production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate).
- Biology, EngineeringBioresource technology
- 2017
A synthetic, light-driven consortium of cyanobacteria and heterotrophic bacteria enables stable polyhydroxybutyrate production.
- BiologyMetabolic engineering
- 2017
Pilot Scale-up of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Production by Halomonas bluephagenesis via Cell Growth Adapted Optimization Process.
- Biology, EngineeringBiotechnology journal
- 2018
A stable and continuous open process for efficient low-cost production of P(3HB-co-4HB) is successfully developed coupling fermentation with the downstream extraction processing.
Overexpression of bifunctional fructose-1,6-bisphosphatase/sedoheptulose-1,7-bisphosphatase leads to enhanced photosynthesis and global reprogramming of carbon metabolism in Synechococcus sp. PCC 7002.
- Environmental Science, BiologyMetabolic engineering
- 2018
Natural and Synthetic Variants of the Tricarboxylic Acid Cycle in Cyanobacteria: Introduction of the GABA Shunt into Synechococcus sp. PCC 7002
- BiologyFront. Microbiol.
- 2016
It is shown that N-acetylornithine aminotransferase (ArgD) can function as a GABA aminotsferase and that, together with glutamate decarboxylase (GadA), it can complete a functional GABA shunt.
Systematic Approaches to Efficiently Produce 2,3-Butanediol in a Marine Cyanobacterium.
- Environmental ScienceACS synthetic biology
- 2017
This work demonstrates the systematic development of a 7002 production strain for the feedstock chemical 2,3-butanediol (23BD) and expands the range of tools available for use in 7002 by identifying and utilizing new integration sites for homologous recombination, demonstrating the inducibility of theophylline riboswitches, and screening a set of isopropyl β-d-1-thiogalactopyranoside inducible promoters.
Challenges and Perspectives of Polyhydroxyalkanoate Production From Microalgae/Cyanobacteria and Bacteria as Microbial Factories: An Assessment of Hybrid Biological System
- Engineering, BiologyFrontiers in Bioengineering and Biotechnology
- 2021
Polyhydroxyalkanoates (PHAs) are the biopolymer of choice if we look for a substitute of petroleum-based non-biodegradable plastics. Microbial production of PHAs as carbon reserves has been studied…
Consequences of ccmR deletion on respiration, fermentation and H2 metabolism in cyanobacterium Synechococcus sp. PCC 7002
- Biology, EngineeringBiotechnology and bioengineering
- 2016
Simultaneous monitoring of the intracellular NAD(P)H concentration and H2 production rate by these mutants reveals an inverse correspondence between these variables indicating hydrogenase‐dependent H 2 production as a major sink for consuming NAD( P)H in preference to excretion of reduced carbon as lactate during fermentation.
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