Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals

@inproceedings{Yu2017MetabolicEO,
  title={Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals},
  author={Tao Yu and Yongjin J Zhou and Leonie Wenning and Quanli Liu and Anastasia Krivoruchko and Verena Siewers and Jens B Nielsen and F. David},
  booktitle={Nature communications},
  year={2017}
}
Production of chemicals and biofuels through microbial fermentation is an economical and sustainable alternative for traditional chemical synthesis. Here we present the construction of a Saccharomyces cerevisiae platform strain for high-level production of very-long-chain fatty acid (VLCFA)-derived chemicals. Through rewiring the native fatty acid elongation system and implementing a heterologous Mycobacteria FAS I system, we establish an increased biosynthesis of VLCFAs in S. cerevisiae… CONTINUE READING

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