Metabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties

@article{Eichenberger2017MetabolicEO,
  title={Metabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties},
  author={Michael Eichenberger and B. J. Lehka and Christophe Folly and David Fischer and S. Martens and E. Sim{\'o}n and Michael Naesby},
  journal={Metabolic Engineering},
  year={2017},
  volume={39},
  pages={80 - 89}
}
Dihydrochalcones are plant secondary metabolites comprising molecules of significant commercial interest as antioxidants, antidiabetics, or sweeteners. To date, their heterologous biosynthesis in microorganisms has been achieved only by precursor feeding or as minor by-products in strains engineered for flavonoid production. Here, the native ScTSC13 was overexpressed in Saccharomyces cerevisiae to increase its side activity in reducing p-coumaroyl-CoA to p-dihydrocoumaroyl-CoA. De novo… Expand
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Biosynthetic Pathway and Metabolic Engineering of Plant Dihydrochalcones.
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