Metabolic engineering of Saccharomyces cerevisiae for production of novel lipid compounds

  title={Metabolic engineering of Saccharomyces cerevisiae for production of novel lipid compounds},
  author={John Dyer and Dorselyn C. Chapital and Jennifer Kuan and Robert Mullen and Armand B. Pepperman},
  journal={Applied Microbiology and Biotechnology},
The yeast Saccharomyces cerevisiae has been modified successfully for production of numerous metabolites and therapeutic proteins through metabolic engineering, but has not been utilized to date for the production of lipid-derived compounds. We developed a lipid metabolic engineering strategy in S. cerevisiae based upon culturing techniques that are typically employed for studies of peroxisomal biogenesis; cells were grown in media containing fatty acids as a sole carbon source, which promotes… CONTINUE READING


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