Metabolic engineering of Klebsiella pneumoniae for the production of cis,cis-muconic acid

Abstract

cis,cis-Muconic acid (ccMA), a metabolic intermediate of Klebsiella pneumoniae, can be converted to adipic acid and terephthalic acid, which are important monomers of synthetic polymers. However, wild-type K. pneumoniae does not produce ccMA because intracellular carbon flow does not favor ccMA biosynthesis. In this study, several metabolic engineering… (More)
DOI: 10.1007/s00253-015-6442-3

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