Metabolic engineering of Escherichia coli for industrial production of glucosamine and N-acetylglucosamine.

@article{Deng2005MetabolicEO,
  title={Metabolic engineering of Escherichia coli for industrial production of glucosamine and N-acetylglucosamine.},
  author={Ming-De Deng and David K Severson and Alan D. Grund and Sarah L Wassink and Richard Paul Burlingame and Alan Berry and Jeffrey Allan Running and Candice A Kunesh and Linsheng Song and Thomas A Jerrell and Reinhardt A. Rosson},
  journal={Metabolic engineering},
  year={2005},
  volume={7 3},
  pages={201-14}
}
Glucosamine and N-acetylglucosamine are currently produced by extraction and acid hydrolysis of chitin from shellfish waste. Production could be limited by the amount of raw material available and the product potentially carries the risk of shellfish protein contamination. Escherichia coli was modified by metabolic engineering to develop a fermentation process. Over-expression of glucosamine synthase (GlmS) and inactivation of catabolic genes increased glucosamine production by 15 fold… CONTINUE READING

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