Metabolic engineering of Bacillus subtilis to enhance the production of tetramethylpyrazine


Bacillus subtilis BS2, which can produce tetramethylpyrazine (TTMP) from glucose, was engineered by knockout of the 2,3-butanediol (2,3-BD) dehydrogenase gene (bdhA) and then regulated through the addition of 2,3-BD to enhance the TTMP yield. The bdhA of B. subtilis BS2 was disrupted to construct a TTMP-producing strain termed BSA. In microaerobic flask… (More)
DOI: 10.1007/s10529-015-1950-x


5 Figures and Tables

Slides referencing similar topics