Metabolic engineering of Bacillus subtilis to enhance the production of tetramethylpyrazine

Abstract

Bacillus subtilis BS2, which can produce tetramethylpyrazine (TTMP) from glucose, was engineered by knockout of the 2,3-butanediol (2,3-BD) dehydrogenase gene (bdhA) and then regulated through the addition of 2,3-BD to enhance the TTMP yield. The bdhA of B. subtilis BS2 was disrupted to construct a TTMP-producing strain termed BSA. In microaerobic flask… (More)
DOI: 10.1007/s10529-015-1950-x

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