Metabolic engineering for improving anthranilate synthesis from glucose in Escherichia coli

@article{BalderasHernndez2009MetabolicEF,
  title={Metabolic engineering for improving anthranilate synthesis from glucose in Escherichia coli},
  author={Victor Emmanuel Balderas-Hern{\'a}ndez and Andrea Sabido-Ramos and Patricia M. Higino da Silva and Natividad Cabrera-Valladares and Georgina Hern{\'a}ndez-Ch{\'a}vez and Jos{\'e} Luis B{\'a}ez-Viveros and Alfredo Martinez and Francisco G Bol{\'i}var and Guillermo Gosset},
  journal={Microbial Cell Factories},
  year={2009},
  volume={8},
  pages={19 - 19}
}
BACKGROUND Anthranilate is an aromatic amine used industrially as an intermediate for the synthesis of dyes, perfumes, pharmaceuticals and other classes of products. Chemical synthesis of anthranilate is an unsustainable process since it implies the use of nonrenewable benzene and the generation of toxic by-products. In Escherichia coli anthranilate is synthesized from chorismate by anthranilate synthase (TrpED) and then converted to phosphoribosyl anthranilate by anthranilate phosphoribosyl… CONTINUE READING

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