Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies.

@article{Goldfine2000MetabolicEO,
  title={Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies.},
  author={Allison B. Goldfine and Mary Elizabeth Patti and Lubna Zuberi and Barry J. Goldstein and Richard Leblanc and Edwin J Landaker and Zhong Yong Jiang and Gail R. Willsky and C Ronald Kahn},
  journal={Metabolism: clinical and experimental},
  year={2000},
  volume={49 3},
  pages={400-10}
}
To investigate the efficacy and mechanism of action of vanadium salts as oral hypoglycemic agents, 16 type 2 diabetic patients were studied before and after 6 weeks of vanadyl sulfate (VOSO4) treatment at three doses. Glucose metabolism during a euglycemic insulin clamp did not increase at 75 mg/d, but improved in 3 of 5 subjects receiving 150 mg VOSO4 and 4 of 8 subjects receiving 300 mg VOSO4. Basal hepatic glucose production (HGP) and suppression of HGP by insulin were unchanged at all doses… CONTINUE READING
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