Metabolic effects of telmisartan in spontaneously hypertensive rats

  title={Metabolic effects of telmisartan in spontaneously hypertensive rats},
  author={Yong-qi Li and Hui Jiao Ji and Yihua Zhang and Da-yong Ding and Xiao-lei Ye},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
The favorable metabolic effects of telmisartan are supposedly related to the changes in carbohydrate and lipid metabolism driven by peroxisome proliferators-activated receptor-γ (PPARγ). The fatty acid translocase CD36 is one of the PPARγ targets that mediate these actions. We studied the metabolic effects of telmisartan in the NIH-derived strain of spontaneously hypertensive rats (SHR/NIH), which harbors a deletion mutation in CD36, in comparison to the original SHRs (SHR/Izm), which express… CONTINUE READING


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