Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects.

  title={Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects.},
  author={Stephan L. Suter and John J. Nolan and Penny Wallace and Barry Gumbiner and Jerrold M. Olefsky},
  journal={Diabetes care},
  volume={15 2},
OBJECTIVE To study the metabolic effects of a new oral antidiabetic agent, CS-045, in subjects with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS Eleven NIDDM subjects (mean age 59 yr and body mass index 32.3) were treated with 400 mg/day CS-045 for 6-12 wk. Patients were hospitalized before and at the end of the drug-treatment period for metabolic studies, including oral glucose tolerance test (OGTT), meal tolerance test (MTT), euglycemic glucose-clamp studies… CONTINUE READING
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