Metabolic effects of indinavir in healthy HIV-seronegative men.

  title={Metabolic effects of indinavir in healthy HIV-seronegative men.},
  author={Mustafa A Noor and Joan C Lo and Kathleen Mulligan and J. M. Schwarz and Robert A. Halvorsen and Morris Schambelan and Carl Grunfeld},
  volume={15 7},
BACKGROUND Therapy with HIV protease inhibitors (PI) has been associated with hyperglycemia, hyperlipidemia and changes in body composition. It is unclear whether these adverse effects are drug related, involve an interaction with the host response to HIV or reflect changes in body composition. METHODS Indinavir 800 mg twice daily was given to 10 HIV-seronegative healthy men to distinguish direct metabolic effects of a PI from those related to HIV infection. Fasting glucose and insulin, lipid… CONTINUE READING


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