• Corpus ID: 38591784

Metabolic effects of glutamine on insulin sensitivity

@article{Molfino2010MetabolicEO,
  title={Metabolic effects of glutamine on insulin sensitivity},
  author={Alessio Molfino and Ferdinando Logorelli and Maurizio Muscaritoli and Antonia Cascino and Isabella Preziosa and Filippo Rossi Fanelli and Alessandro Laviano},
  journal={Nutritional therapy \& metabolism},
  year={2010},
  volume={28},
  pages={7-11}
}
Glutamine, the most abundant free amino acid in human plasma, has outstanding nutritional and non-nutritional properties. Glutamine regulates immune function and modulates cell metabolism. In particular, its administration showed a positive effect on glucose oxidation and on insulin resistance in different experimental and clinical studies. In humans, glutamine acts as both a substrate and modulator of its metabolism to glucose. In trauma patients and in critical illness, parenteral glutamine… 

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TLDR
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TLDR
The stimulatory effects of glutamine on gluconeogenesis occurred in the absence of changes in plasma insulin and glucagon levels, and these results provide evidence that, in humans, glutamine may act both as a substrate and as a regulator of gluc oneogenesis as well as a modulator of its own metabolism.

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TLDR
It is hypothesized that glutamine plays a critical role as a signaling molecule in amino acid- and glucose-stimulated insulin secretion, and that β-cell depolarization and subsequent intracellular calcium elevation are required for this glutamine effect to occur.

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TLDR
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TLDR
Glutamine effectively increases circulating GLP-1, GIP, and insulin concentrations in vivo and may represent a novel therapeutic approach to stimulating insulin secretion in obesity and type 2 diabetes.

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TLDR
Parenteral supplementation of alanyl-glutamine dipeptide was associated with better insulin sensitivity in multiple-trauma patients and the main glucose homeostasis variables in group C between days 4 and 8 of the study was statistically significant; however, differences in these variables in groups AG were without statistical significance.

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TLDR
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TLDR
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TLDR
Treating hyperglycemia improves skeletal muscle protein and amino acid metabolism in cancer patients after major surgery and is associated with higher fractional glucose uptake and higher muscle protein synthesis and neutral net protein balance.
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