• Corpus ID: 38591784

Metabolic effects of glutamine on insulin sensitivity

  title={Metabolic effects of glutamine on insulin sensitivity},
  author={Alessio Molfino and Ferdinando Logorelli and Maurizio Muscaritoli and Antonia Cascino and Isabella Preziosa and Filippo Rossi Fanelli and Alessandro Laviano},
  journal={Nutritional therapy \& metabolism},
Glutamine, the most abundant free amino acid in human plasma, has outstanding nutritional and non-nutritional properties. Glutamine regulates immune function and modulates cell metabolism. In particular, its administration showed a positive effect on glucose oxidation and on insulin resistance in different experimental and clinical studies. In humans, glutamine acts as both a substrate and modulator of its metabolism to glucose. In trauma patients and in critical illness, parenteral glutamine… 

Therapeutic Targets of Glutamine in Parenteral Nutrition: A Medical Science Review

There is a mandatory need for more clinical trials, which could address the clinical concerns of glutamine supplementation to parenteral nutrition and based on the current clinical studies, the use of glutamines is still a clinical and economically attractive management strategy.

A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

Glutamine supplementation could improve glycemic control and levels of incretins (such as GLP-1 and GIP) in diabetes mellitus, however, more studies are needed for future studies.

Repurposing statin and L-glutamine: replenishing β-cells in hyperlipidemic T2D mouse model

While cases of obesity-induced type 2 diabetes (T2D) are on the upswing, current therapies help only manage the symptoms. Of late, L-glutamine has been implicated in the amelioration of T2D by virtue

Effects of whey protein supplements on metabolism: evidence from human intervention studies

Evidence for a clinical efficacy is not strong enough to make final recommendations with respect to a specific dose and the duration of supplementation on the effects of whey protein on metabolic disorders and the musculoskeletal system.

Management of Hyperglycemia in Hospitalized Patients Receiving Parenteral Nutrition

The aim of this review is to give an overview of the management of parenteral nutrition-associated hyperglycemia in inpatients with diabetes.

Metabolomic Analysis of Serum and Tear Samples from Patients with Obesity and Type 2 Diabetes Mellitus

It is found that BCAA and glutamine metabolism, urea cycle, and beta-oxidation make up crucial parts of the metabolic changes in T2D and can be relevant pathways to understanding and treating insulin resistance.

The Effect of Supplementing Sodium Butyrate Containing Feed with Glutamine and/or Glucose on the Structure of the Piglet Digestive Tract and Selected Blood Indices

It is concluded that glutamine and glucose, when given together with sodium butyrate, improve the structure of piglet jejunum epithelium and average body weight gains.

Utilization of Snakehead Fish Meat for Increasing Kidney Function in Rat Experiencing Physiological Stress

The supplementation of snakehead fish with concentration of 5% to 20% did not affect the number of glomerulus of Wistar rats with physiological stress and this study is useful as information for people who study the mechanism of kidney repair due to physiological stress.



Nonnutritive effects of glutamine.

  • E. Roth
  • Biology
    The Journal of nutrition
  • 2008
Glutamine deprivation reduces proliferation of lymphocytes, influences expression of surface activation markers on lymphocytes and monocytes, affects the production of cytokines, and stimulates apoptosis, and glutamine administration seems to have a positive effect on glucose metabolism in the state of insulin resistance.

Regulation of gluconeogenesis by glutamine in normal postabsorptive humans.

The stimulatory effects of glutamine on gluconeogenesis occurred in the absence of changes in plasma insulin and glucagon levels, and these results provide evidence that, in humans, glutamine may act both as a substrate and as a regulator of gluc oneogenesis as well as a modulator of its own metabolism.

A Signaling Role of Glutamine in Insulin Secretion*

It is hypothesized that glutamine plays a critical role as a signaling molecule in amino acid- and glucose-stimulated insulin secretion, and that β-cell depolarization and subsequent intracellular calcium elevation are required for this glutamine effect to occur.

Effects of physiological hyperinsulinemia on systemic, renal, and hepatic substrate metabolism.

To determine the effect of physiological hyperinsulinemia on renal and hepatic substrate metabolism, systems and renal gluconeogenesis from glutamine, and certain aspects of systemic and renal glutamine and free fatty acid (FFA) metabolism were assessed.

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.

Glutamine effectively increases circulating GLP-1, GIP, and insulin concentrations in vivo and may represent a novel therapeutic approach to stimulating insulin secretion in obesity and type 2 diabetes.

Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients

Parenteral supplementation of alanyl-glutamine dipeptide was associated with better insulin sensitivity in multiple-trauma patients and the main glucose homeostasis variables in group C between days 4 and 8 of the study was statistically significant; however, differences in these variables in groups AG were without statistical significance.

The oxidative stress of hyperglycemia and the inflammatory process in endothelial cells.

Results demonstrate that a combination of insulin and glutamine are significantly more effective in reducing the expression of IL-8, TNF-alpha and HO-1 than insulin or glutamine alone.

Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus.

The inter-organ flux of substrates after a protein-rich meal was studied in seven healthy subjects and in eight patients, with diabetes mellitus, and there was a large amino acid release from the splanchnic bed predominantly involving the branched chain amino acids.

Treating hyperglycemia improves skeletal muscle protein metabolism in cancer patients after major surgery

Treating hyperglycemia improves skeletal muscle protein and amino acid metabolism in cancer patients after major surgery and is associated with higher fractional glucose uptake and higher muscle protein synthesis and neutral net protein balance.