Metabolic effects of contraceptive steroids

@article{SitrukWare2011MetabolicEO,
  title={Metabolic effects of contraceptive steroids},
  author={R{\'e}gine Sitruk-Ware and Anita Nath},
  journal={Reviews in Endocrine and Metabolic Disorders},
  year={2011},
  volume={12},
  pages={63-75}
}
Estrogen and progestins have been used by millions of women as effective combined contraceptives. The safety of hormonal contraceptives has been documented by years of follow-up and serious adverse events that may be related to their use are rare in the young population exposed to these agents. The balance between the benefits and the risks of contraceptive steroids is generally positive in particular when comparing to the risks of pregnancy and especially in women with risk factors. The… 
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References

SHOWING 1-10 OF 104 REFERENCES
Contraceptive hormone use and cardiovascular disease.
Different cardiovascular effects of progestins according to structure and activity
  • A. Nath, R. Sitruk-Ware
  • Biology, Medicine
    Climacteric : the journal of the International Menopause Society
  • 2009
TLDR
Although it is likely that the new progestins may be neutral on the coronary disease risk, when administered to the younger postmenopausal woman, this has not as yet been documented by large, randomized, controlled trials.
Mechanisms of sex steroids. Future developments.
  • H. Kuhl
  • Biology, Medicine
    Maturitas
  • 2004
Metabolic effects of implantable steroid contraceptives for women.
Evaluation of a new estradiol oral contraceptive: estradiol valerate and dienogest
  • J. Jensen
  • Medicine
    Expert opinion on pharmacotherapy
  • 2010
TLDR
The dynamic-dosing E2V/DNG oral contraceptive pill provides a highly effective contraceptive option with an adjusted Pearl Index of 0.51 (upper limit of 95% CI 0.97) and unadjusted Pearl Index (user failure) for women aged 18 – 35 years.
Effects of transdermal and oral contraceptives on estrogen-sensitive hepatic proteins.
New progestagens for contraceptive use.
TLDR
Several new progestins, including dienogest (DNG), drospirenone (DRSP), Nestorone (NES), nomegestrol acetate (NOMAc) and trimegestone (TMG) have been synthesized in the last two decades, designed to have no androgenic or estrogenic actions and to be closer to the physiological hormone P.
Effect of oral contraceptives on haemostasis variables.
TLDR
The role of PGs in the effects of COCs is significant and their design may in addition to reduction of oestrogen dosage be important in reducing haemostatic complications, according to summarised literature data.
...
1
2
3
4
5
...