Metabolic effects of carbenoxolone in rat liver.

  title={Metabolic effects of carbenoxolone in rat liver.},
  author={Leandro Silva Pivato and Rodrigo Polimeni Constantin and Emy Luiza Ishii-Iwamoto and Ana Maria Kelmer-Bracht and Nair Seiko Yamamoto and J. Constantin and Adelar Bracht},
  journal={Journal of biochemical and molecular toxicology},
  volume={20 5},
The action of carbenoxolone on hepatic energy metabolism was investigated in the perfused rat liver and isolated mitochondria. In perfused livers, carbenoxolone (200-300 microM) increased oxygen consumption, glucose production and glycolysis from endogenous glycogen. Gluconeogenesis from lactate or fructose, an energy-dependent process, was inhibited. This effect was already evident at a concentration of 25 microM. The cellular ATP levels and the adenine nucleotide content were decreased by… CONTINUE READING
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