Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials

  title={Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials},
  author={Natalia Santos and Laiza Magalhaes de Araujo and G. De Luca Canto and E. Guerra and M. S. Coelho and M. Borin},
  journal={Critical Reviews in Food Science and Nutrition},
  pages={2068 - 2081}
ABSTRACT Data about harms or benefits associated with the consumption of aspartame, a nonnutritive sweetener worldwide consumed, are still controversial. This systematic review and meta-analysis of randomized controlled clinical trials aimed to assess the effect of aspartame consumption on metabolic parameters related to diabetes and obesity. The search was performed on Cochrane, LILACS, PubMed, SCOPUS, Web of Science databases, and on a gray literature using Open Grey, Google Scholar, and… Expand

Paper Mentions

The effect of the artificial sweeteners on glucose metabolism in healthy adults: a randomized double-blinded crossover clinical trial.
It is suggested that daily repeated consumption of pure sucralose or aspartame for 2 weeks had no effect on glucose metabolism among normoglycaemic adults, however, these results need to be tested in studies with longer durations. Expand
Nonalcoholic fatty liver disease, insulin resistance, and sweeteners: a literature review
An up-to-date systematic review of the current literature regarding the safety in artificial and natural sweeteners use as a means of weight loss or diabetes control concludes that rare sugars and polyols can be used safely and have significant benefits that include anti-oxidant effect and optimal glycemic control. Expand
Low-calorie sweeteners and human health: a rapid review of systematic reviews.
The aim of this review was to summarize the evidence from systematic reviews on low-calorie sweetener use and chronic conditions and risk factors in children and adults and suggest continued research on the long-term health impacts of low-Calorie sweeteners across all life stages is warranted. Expand
Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews
A scoping review of reviews was conducted to obtain an overview of hypotheses, research approaches and features of the evidence on intense sweeteners’ potential relationships to appetite and weight changes, finding that with few exceptions, the reviews on intensesweeteners and weight change underuse systematic methodology. Expand
The Impact of Artificial Sweeteners on Body Weight Control and Glucose Homeostasis
The majority of clinical studies performed thus far report no significant effects or beneficial effects of artificial sweeteners on body weight and glycemic control, but it should be emphasized that the study duration of most studies was limited. Expand
Acute Impact of Artificial Sweetener, Aspartame on Blood Parameter in Mice
It is concluded that the ingestion of aspartame using the above doses has acute impact and is not dose-dependent on blood parameters which could exert further, on the long run, health risks on to other tissues of consumers. Expand
Dietary intakes of six intense sweeteners by Irish adults
Intakes of the six intense sweeteners are currently not a concern among Irish adults, however, exposure to these chemicals should be monitored on a regular basis due to evolving market and consumption patterns. Expand
Partial substitution of sucrose by non-nutritive sweeteners in sour orange marmalades: effects on quality characteristics and acute postprandial glycemic response in healthy volunteers
Background: Overconsumption of added sugars, particularly refined sugars, has been shown to be associated with adverse health concerns. Aim: The present study aimed to elaborate calorie-reducedExpand
Medical Nutrition Therapy in Obesity Management
• Healthy eating is important for all Canadians, regardless of body size, weight or health status. Key messages from Canada’s Food Guide for Healthy Eating can be used as a foundation for nutritionExpand
Assessment of the effect of artificial sweeteners on glucose metabolism and gut microbiota
.............................................................................................................................................. II ACKNOWLEDGEMENTExpand


Aspartame Sensitivity? A Double Blind Randomised Crossover Study
This independent study gives reassurance to both regulatory bodies and the public that acute ingestion of aspartame does not have any detectable psychological or metabolic effects in humans. Expand
Aspartame: A Safety Evaluation Based on Current Use Levels, Regulations, and Toxicological and Epidemiological Studies
The data from the extensive investigations into the possibility of neurotoxic effects of aspartame, in general, do not support the hypothesis that aspartam in the human diet will affect nervous system function, learning or behavior. Expand
The incidence of comorbidities related to obesity and overweight : A systematic review and meta-analysis
Background: Overweight and obese persons are at risk of a number of medical conditions which can lead to further morbidity and mortality. The primary objective of this study is to provide an estimateExpand
Aspartame: review of safety.
The safety testing of aspartame has gone well beyond that required to evaluate the safety of a food additive, and there are no unresolved questions regarding its safety under conditions of intended use. Expand
Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies
The balance of evidence indicates that use of LES in place of sugar, in children and adults, leads to reduced EI and BW, and possibly also when compared with water. Expand
The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis
Both overweight and obesity are associated with the incidence of multiple co-morbidities including type II diabetes, cancer and cardiovascular diseases, and maintenance of a healthy weight could be important in the prevention of the large disease burden in the future. Expand
An evaluation of the effect of aspartame on weight loss
It is suggested possible advantages to supplementing a BDD with aspartame-sweetened foods as part of a multidisciplinary weight loss program and the small sample size prohibits definitive conclusions but does provide the protocol for a larger, outpatient clinical trial. Expand
The Neuropsychiatric Effects of Aspartame in Normal Volunteers
Following a single 15 mg/kg dose of aspartame, no detectable effects are observed in a group of healthy volunteers with no history of as partame intolerance, despite significant increases in plasma phenylalanine concentrations. Expand
Administration of aspartame in non-insulin-dependent diabetics.
Aspartame seems to be well tolerated by non-insulin-dependent diabetics, and diabetic control was unaffected by the chronic administration of these substances. Expand
A review of the effectiveness of aspartame in helping with weight control
The evidence for the effect of aspartame on weight loss, weight maintenance and energy intakes in adults is reviewed and the question of how much energy is compensated for and whether the use of as partame-sweetened foods and drinks is an effective way to lose weight is addressed. Expand