Metabolic effects of a growth hormone-releasing factor in patients with HIV.

  title={Metabolic effects of a growth hormone-releasing factor in patients with HIV.},
  author={Julian M Falutz and Soraya Allas and Koenraad Blot and Diane Potvin and Donald Kotler and Michael S Somero and Daniel Berger and Stephen Scott Brown and Gary Richmond and Jeffrey Fessel and Ralph O Turner and Steven Grinspoon},
  journal={The New England journal of medicine},
  volume={357 23},
BACKGROUND Visceral adipose tissue accumulates during antiretroviral therapy in many patients who are infected with the human immunodeficiency virus (HIV); this process is associated with an increased cardiovascular risk. We assessed the use of a growth hormone-releasing factor analogue, tesamorelin, to decrease visceral adiposity. METHODS We randomly assigned 412 patients with HIV (86% of whom were men) who had an accumulation of abdominal fat to receive a daily subcutaneous injection of… CONTINUE READING


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