Metabolic effects and fate of succinate esters in pancreatic islets.

  title={Metabolic effects and fate of succinate esters in pancreatic islets.},
  author={Willy Jean Malaisse and Abdullah Sener},
  journal={The American journal of physiology},
  volume={264 3 Pt 1},
The metabolic effects and the catabolism of succinate methyl esters were examined in rat pancreatic islets. The esters augmented 14CO2 production from islets prelabeled with L-[U-14C]-glutamine but inhibited NH4+ output, suggesting that they do not activate glutamate dehydrogenase. They decreased 14CO2 output from islets prelabeled with [U-14C]palmitate. They had little effect on the oxidation of exogenous D-[3,4-14C]glucose, D-[2-14C]glucose, D-[6-14C]glucose, or D-[1-14C]glucose, suggesting… CONTINUE READING
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