Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.

@article{Kratz2014MetabolicDD,
  title={Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.},
  author={Mario Kratz and Brittney R Coats and Katherine B. Hisert and Derek K Hagman and Vesco Mutskov and Eduard Peris and Kelly Q. Schoenfelt and Jessica N Kuzma and Ilona Larson and Peter S Billing and Robert W Landerholm and Matthew R Crouthamel and David Gozal and Seungmin Hwang and Pradeep K. Singh and Lev Becker},
  journal={Cell metabolism},
  year={2014},
  volume={20 4},
  pages={614-25}
}
Adipose tissue macrophage (ATM)-driven inflammation plays a key role in insulin resistance; however, factors activating ATMs are poorly understood. Using a proteomics approach, we show that markers of classical activation are absent on ATMs from obese humans but are readily detectable on airway macrophages of patients with cystic fibrosis, a disease associated with chronic bacterial infection. Moreover, treating macrophages with glucose, insulin, and palmitate-conditions characteristic of the… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 4 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 99 extracted citations

Role of lipids in the metabolism and activation of immune cells.

The Journal of nutritional biochemistry • 2016
View 10 Excerpts
Highly Influenced

STAT4 contributes to adipose tissue inflammation and atherosclerosis.

The Journal of endocrinology • 2015
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Tlr2 is critical for diet-induced metabolic syndrome in a murine model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2010
View 8 Excerpts
Highly Influenced

Nutrient sensing and inflammation in metabolic diseases

Nature Reviews Immunology • 2008
View 5 Excerpts
Highly Influenced

TLR4 links innate immunity and fatty acid-induced insulin resistance.

The Journal of clinical investigation • 2006
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…