Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.

  title={Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.},
  author={Mario Kratz and Brittney R Coats and Katherine B. Hisert and Derek K Hagman and Vesco Mutskov and Eduard Peris and Kelly Q. Schoenfelt and Jessica N Kuzma and Ilona Larson and Peter S Billing and Robert W Landerholm and Matthew R Crouthamel and David Gozal and Seungmin Hwang and Pradeep K. Singh and Lev Becker},
  journal={Cell metabolism},
  volume={20 4},
Adipose tissue macrophage (ATM)-driven inflammation plays a key role in insulin resistance; however, factors activating ATMs are poorly understood. Using a proteomics approach, we show that markers of classical activation are absent on ATMs from obese humans but are readily detectable on airway macrophages of patients with cystic fibrosis, a disease associated with chronic bacterial infection. Moreover, treating macrophages with glucose, insulin, and palmitate-conditions characteristic of the… CONTINUE READING
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