Metabolic dysfunction and depletion of mitochondria in hearts of septic rats.

@article{Watts2004MetabolicDA,
  title={Metabolic dysfunction and depletion of mitochondria in hearts of septic rats.},
  author={John Albert Watts and Jeffrey A. Kline and Lisa R Thornton and Richard Grattan and Sukhdev S. Brar},
  journal={Journal of molecular and cellular cardiology},
  year={2004},
  volume={36 1},
  pages={141-50}
}
Our previous studies indicate that hearts from septic rats have decreased work with oxygen wasting. The present studies test if there is energy deficit, changes in cardiac mitochondrial content and caspase activation during sepsis. Anesthetized, male Sprague-Dawley rats received no surgical treatment (control), laparotomy (sham), or laparotomy with cecal ligation and puncture (CLP) to induce polymicrobial septic shock. Hearts were isolated 12-14 h later. Cardiac work, oxygen consumption… CONTINUE READING