Metabolic downregulation: a key to successful neuroprotection?

  title={Metabolic downregulation: a key to successful neuroprotection?},
  author={Midori A Yenari and Kazuo Kitagawa and Patrick T Lyden and Miguel A. P{\'e}rez-Pinz{\'o}n},
  volume={39 10},
BACKGROUND AND PURPOSE The search for effective neuroprotectants remains frustrating, particularly with regard to specific pharmaceuticals. However, laboratory studies have consistently shown remarkable neuroprotection with 2 nonpharmacological strategies-therapeutic hypothermia and ischemic preconditioning. Recent studies have shown that the mechanism of protection underlying both of these treatments is correlated to downregulation of cellular and tissue metabolism. Thus, understanding the… CONTINUE READING
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