Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance.

@article{Vgontzas2003MetabolicDI,
  title={Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance.},
  author={Alexandros N. Vgontzas and Edward Oren Bixler and George P. Chrousos},
  journal={Journal of internal medicine},
  year={2003},
  volume={254 1},
  pages={
          32-44
        }
}
Obstructive sleep apnoea (OSA) is a very prevalent disorder particularly amongst middle-aged, obese men, although its existence in women as well as in lean individuals is increasingly recognized. Despite the early recognition of the strong association between OSA and obesity, and OSA and cardiovascular problems, sleep apnoea has been treated as a 'local abnormality' of the respiratory track rather than as a 'systemic illness'. In 1997, we first reported that the pro-inflammatory cytokines… CONTINUE READING
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