Metabolic disposition of 14C-venlafaxine in mouse, rat, dog, rhesus monkey and man.

@article{Howell1993MetabolicDO,
  title={Metabolic disposition of 14C-venlafaxine in mouse, rat, dog, rhesus monkey and man.},
  author={Stanley R. Howell and G E Husbands and Joann Scatina and S. F. Sisenwine},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1993},
  volume={23 4},
  pages={349-59}
}
1. The metabolic disposition of venlafaxine has been studied in mouse, rat, dog, rhesus monkey and man after oral doses (22, 22, 2, and 10 mg/kg, and 50 mg, respectively) of 14C-venlafaxine as the hydrochloride. 2. In all species, over 85% of the administered radioactivity was recovered in the urine within 72 h, indicating extensive absorption from the GI tract and renal excretion. 3. Venlafaxine was extensively metabolized, with only 13.0, 1.8, 7.9, 0.3 and 4.7% dose appearing as parent… CONTINUE READING

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