Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseases.

@article{Monte2012MetabolicDM,
  title={Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseases.},
  author={Suzanne de la Monte},
  journal={Panminerva medica},
  year={2012},
  volume={54 3},
  pages={171-8}
}
Herein, we review evidence that systemic insulin-resistance diseases linked to obesity, type 2 diabetes, and non-alcoholic steatohepatitis promote neurodegeneration. Insulin-resistance dysregulates lipid metabolism, which promotes ceramide accumulation with attendant inflammation and endoplasmic reticulum (ER) stress. Mechanistically, we propose that toxic ceramides generated in extra-CNS tissues, e.g. liver, get released into peripheral blood, and subsequently transit across the blood-brain… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Role of insulin resistance in Alzheimer’s disease

Metabolic Brain Disease • 2014
View 5 Excerpts
Highly Influenced

Induction of innervation by encapsulated adipocytes with engineered vitamin A metabolism.

Translational research : the journal of laboratory and clinical medicine • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…